Title : Inhibition of basal and tumor necrosis factor-enhanced binding of murine tumor cells to murine endothelium by transforming growth factor-beta 1.

Pub. Date : 1992 May 1

PMID : 1315361






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 The TGF-beta-mediated inhibition of P815 basal binding to endothelium is dependent on protein synthesis because cycloheximide reverses the TGF-beta effect. Cycloheximide transforming growth factor, beta 1 Mus musculus
2 The TGF-beta-mediated inhibition of P815 basal binding to endothelium is dependent on protein synthesis because cycloheximide reverses the TGF-beta effect. Cycloheximide transforming growth factor, beta 1 Mus musculus
3 However, TGF-beta-mediated inhibition of both basal binding and TNF-enhanced P815 binding to MME is completely abolished in the presence of the protein phosphatase inhibitor okadaic acid which suggests that TGF-beta may elicit its effect by stimulating protein phosphatase activity. Okadaic Acid transforming growth factor, beta 1 Mus musculus
4 However, TGF-beta-mediated inhibition of both basal binding and TNF-enhanced P815 binding to MME is completely abolished in the presence of the protein phosphatase inhibitor okadaic acid which suggests that TGF-beta may elicit its effect by stimulating protein phosphatase activity. Okadaic Acid transforming growth factor, beta 1 Mus musculus