Pub. Date : 1992 Apr
PMID : 1312937
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tumor necrosis factor-mediated cell lysis in vitro: relationship to cAMP accumulation and guanine nucleotide-binding proteins. | Cyclic AMP | tumor necrosis factor | Homo sapiens |
| 2 | Tumor necrosis factor-mediated cell lysis in vitro: relationship to cAMP accumulation and guanine nucleotide-binding proteins. | Guanine Nucleotides | tumor necrosis factor | Homo sapiens |
| 3 | We have investigated the modulation of tumor necrosis factor (TNF)-mediated tumor cell lysis by cAMP. | Cyclic AMP | tumor necrosis factor | Homo sapiens |
| 4 | We have investigated the modulation of tumor necrosis factor (TNF)-mediated tumor cell lysis by cAMP. | Cyclic AMP | tumor necrosis factor | Homo sapiens |
| 5 | To study the relationship between TNF-mediated cell lysis and cAMP accumulation, cAMP measurement was performed following TNF treatment. | Cyclic AMP | tumor necrosis factor | Homo sapiens |
| 6 | Experiments in which cells were exposed to forskolin revealed that this cAMP elevating drug was efficient in enhancing the sensitivity to TNF of MCF7 cell line. | Colforsin | tumor necrosis factor | Homo sapiens |
| 7 | Experiments in which cells were exposed to forskolin revealed that this cAMP elevating drug was efficient in enhancing the sensitivity to TNF of MCF7 cell line. | Cyclic AMP | tumor necrosis factor | Homo sapiens |
| 8 | This potentiating effect of forskolin was maximal for suboptimal concentrations of TNF (10 ng/ml), reaching up to 100% when forskolin was added at 100 microM. | Colforsin | tumor necrosis factor | Homo sapiens |
| 9 | This potentiating effect of forskolin was maximal for suboptimal concentrations of TNF (10 ng/ml), reaching up to 100% when forskolin was added at 100 microM. | Colforsin | tumor necrosis factor | Homo sapiens |
| 10 | However, co-stimulating with forskolin of either MDA MB 231 or a TNF-resistant MCF7 clone (MCF7-R-A1) did not induce any reversal of resistance to TNF. | Colforsin | tumor necrosis factor | Homo sapiens |
| 11 | In contrast, pertussis toxin-catalyzed ADP ribosylation experiments suggest a functional coupling of TNF receptors to a 40-kDa pertussis toxin-sensitive G-protein in the TNF-sensitive MCF78 cell line but not in the TNF-resistant MDA MB 231 cell line. | Adenosine Diphosphate | tumor necrosis factor | Homo sapiens |
| 12 | In contrast, pertussis toxin-catalyzed ADP ribosylation experiments suggest a functional coupling of TNF receptors to a 40-kDa pertussis toxin-sensitive G-protein in the TNF-sensitive MCF78 cell line but not in the TNF-resistant MDA MB 231 cell line. | Adenosine Diphosphate | tumor necrosis factor | Homo sapiens |
| 13 | In contrast, pertussis toxin-catalyzed ADP ribosylation experiments suggest a functional coupling of TNF receptors to a 40-kDa pertussis toxin-sensitive G-protein in the TNF-sensitive MCF78 cell line but not in the TNF-resistant MDA MB 231 cell line. | Adenosine Diphosphate | tumor necrosis factor | Homo sapiens |
| 14 | Taken together, these data indicate that cAMP might play a role in TNF-mediated cell lysis and are in support of the involvement of a pertussis toxin-sensitive G-protein in TNF-mediated MCF7 cells lysis. | Cyclic AMP | tumor necrosis factor | Homo sapiens |
| 15 | Taken together, these data indicate that cAMP might play a role in TNF-mediated cell lysis and are in support of the involvement of a pertussis toxin-sensitive G-protein in TNF-mediated MCF7 cells lysis. | Cyclic AMP | tumor necrosis factor | Homo sapiens |