Title : The effect of tumor necrosis factor-alpha on human malignant glial cells.

Pub. Date : 1992 Apr

PMID : 1312141






1 Functional Relationships(s)
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1 The results of this study demonstrate that tumor necrosis factor-alpha at doses of 50 and 100 ng/ml: 1) did not have cytotoxic or cytostatic effects on the U-251 cell line; 2) significantly increased the intracellular activity of manganese superoxide dismutase but had no effect on copper and zinc superoxide dismutase, catalase, or glutathione peroxidase activity; and 3) did not significantly alter the intracellular or extracellular general protease and collagenase type IV activity of these cells. Copper tumor necrosis factor Homo sapiens