Title : Acid lability is not an intrinsic property of interferon-alpha induced by HIV-infected cells.

Pub. Date : 1992 Dec

PMID : 1289411






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Al-IFN-alpha is a mixture of both glycosylated and unglycosylated molecules as shown by separation on Concanavalin-A Sepharose. Sepharose interferon alpha 1 Homo sapiens
2 Upon chromatography of the glycosylated fraction on Sepharose coupled to IFN-alpha-specific antibody, the portion of the IFN that is retained and eluted with guanidine-HCl is acid-stable, whereas the excluded antiviral activity is acid-labile, and is partially neutralized by antibodies to either IFN-alpha or IFN-gamma. Guanidine interferon alpha 1 Homo sapiens