Title : Evidence for the involvement of GABA(A) receptor blockade in convulsions induced by cephalosporins.

Pub. Date : 2003 Sep

PMID : 12871648






3 Functional Relationships(s)
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1 The proposed mechanism is suppression of inhibitory postsynaptic responses, mainly mediated by gamma-amino butyric acid (GABA)(A)-receptors (GABA(A)-R). gamma-Aminobutyric Acid gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
2 The proposed mechanism is suppression of inhibitory postsynaptic responses, mainly mediated by gamma-amino butyric acid (GABA)(A)-receptors (GABA(A)-R). gamma-Aminobutyric Acid gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
3 These results clearly demonstrate that the mechanism of cephalosporin-induced convulsions is mediated predominantly through the inhibition of GABA(A)-R function and not through NMDA receptor modulation. Cephalosporins gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus