Pub. Date : 2003 Aug
PMID : 12842860
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Northern blot analysis revealed high levels of Nox4 transcript in MCs and transfection with antisense (AS) oligonucleotides for Nox4 markedly decreased NADPH-dependent reactive oxygen species (ROS)-producing activity. | Oligonucleotides, Antisense | NADPH oxidase 4 | Homo sapiens |
2 | Northern blot analysis revealed high levels of Nox4 transcript in MCs and transfection with antisense (AS) oligonucleotides for Nox4 markedly decreased NADPH-dependent reactive oxygen species (ROS)-producing activity. | Oligonucleotides, Antisense | NADPH oxidase 4 | Homo sapiens |
3 | Northern blot analysis revealed high levels of Nox4 transcript in MCs and transfection with antisense (AS) oligonucleotides for Nox4 markedly decreased NADPH-dependent reactive oxygen species (ROS)-producing activity. | NADP | NADPH oxidase 4 | Homo sapiens |
4 | Northern blot analysis revealed high levels of Nox4 transcript in MCs and transfection with antisense (AS) oligonucleotides for Nox4 markedly decreased NADPH-dependent reactive oxygen species (ROS)-producing activity. | Reactive Oxygen Species | NADPH oxidase 4 | Homo sapiens |
5 | Northern blot analysis revealed high levels of Nox4 transcript in MCs and transfection with antisense (AS) oligonucleotides for Nox4 markedly decreased NADPH-dependent reactive oxygen species (ROS)-producing activity. | Reactive Oxygen Species | NADPH oxidase 4 | Homo sapiens |
6 | Dominant negative Rac1 (N17Rac1) as well as AS Nox4 inhibited ROS generation in response to ANG II and AA, whereas constitutively active Rac1 stimulated ROS formation. | Reactive Oxygen Species | NADPH oxidase 4 | Homo sapiens |
7 | These data provide the first evidence that activation by AA of a Rac1-regulated, Nox4-based NAD(P)H oxidase and subsequent generation of ROS mediate the effect of ANG II on Akt/PKB activation and protein synthesis in MCs. | Reactive Oxygen Species | NADPH oxidase 4 | Homo sapiens |