Title : Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells.

Pub. Date : 2003 Aug

PMID : 12842860






7 Functional Relationships(s)
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1 Northern blot analysis revealed high levels of Nox4 transcript in MCs and transfection with antisense (AS) oligonucleotides for Nox4 markedly decreased NADPH-dependent reactive oxygen species (ROS)-producing activity. Oligonucleotides, Antisense NADPH oxidase 4 Homo sapiens
2 Northern blot analysis revealed high levels of Nox4 transcript in MCs and transfection with antisense (AS) oligonucleotides for Nox4 markedly decreased NADPH-dependent reactive oxygen species (ROS)-producing activity. Oligonucleotides, Antisense NADPH oxidase 4 Homo sapiens
3 Northern blot analysis revealed high levels of Nox4 transcript in MCs and transfection with antisense (AS) oligonucleotides for Nox4 markedly decreased NADPH-dependent reactive oxygen species (ROS)-producing activity. NADP NADPH oxidase 4 Homo sapiens
4 Northern blot analysis revealed high levels of Nox4 transcript in MCs and transfection with antisense (AS) oligonucleotides for Nox4 markedly decreased NADPH-dependent reactive oxygen species (ROS)-producing activity. Reactive Oxygen Species NADPH oxidase 4 Homo sapiens
5 Northern blot analysis revealed high levels of Nox4 transcript in MCs and transfection with antisense (AS) oligonucleotides for Nox4 markedly decreased NADPH-dependent reactive oxygen species (ROS)-producing activity. Reactive Oxygen Species NADPH oxidase 4 Homo sapiens
6 Dominant negative Rac1 (N17Rac1) as well as AS Nox4 inhibited ROS generation in response to ANG II and AA, whereas constitutively active Rac1 stimulated ROS formation. Reactive Oxygen Species NADPH oxidase 4 Homo sapiens
7 These data provide the first evidence that activation by AA of a Rac1-regulated, Nox4-based NAD(P)H oxidase and subsequent generation of ROS mediate the effect of ANG II on Akt/PKB activation and protein synthesis in MCs. Reactive Oxygen Species NADPH oxidase 4 Homo sapiens