Title : Posttranscriptional regulation of albumin and alpha-fetoprotein messenger RNA by transforming growth factor-beta 1 requires de novo RNA and protein synthesis.

Pub. Date : 1992 Nov

PMID : 1282669






6 Functional Relationships(s)
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1 Pretreatment with actinomycin-D prevented the TGF beta 1-induced decrease in albumin and AFP mRNA levels. Dactinomycin transforming growth factor, beta 1 Mus musculus
2 Also, if cells were treated with actinomycin-D after a 12-h exposure to TGF beta 1, actinomycin-D abrogated the further decrease in albumin and AFP mRNA levels that occurred after treatment with TGF beta 1 alone. Dactinomycin transforming growth factor, beta 1 Mus musculus
3 Also, if cells were treated with actinomycin-D after a 12-h exposure to TGF beta 1, actinomycin-D abrogated the further decrease in albumin and AFP mRNA levels that occurred after treatment with TGF beta 1 alone. Dactinomycin transforming growth factor, beta 1 Mus musculus
4 Also, if cells were treated with actinomycin-D after a 12-h exposure to TGF beta 1, actinomycin-D abrogated the further decrease in albumin and AFP mRNA levels that occurred after treatment with TGF beta 1 alone. Dactinomycin transforming growth factor, beta 1 Mus musculus
5 Also, if cells were treated with actinomycin-D after a 12-h exposure to TGF beta 1, actinomycin-D abrogated the further decrease in albumin and AFP mRNA levels that occurred after treatment with TGF beta 1 alone. Dactinomycin transforming growth factor, beta 1 Mus musculus
6 Cycloheximide pretreatment blocked the TGF beta 1-induced decrease in albumin and AFP mRNA levels. Cycloheximide transforming growth factor, beta 1 Mus musculus