Title : Modulation of tumor necrosis factor-induced increase in renal (LLC-PK1) transepithelial permeability.

Pub. Date : 1992 Nov

PMID : 1279987






3 Functional Relationships(s)
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1 The tyrosine kinase inhibitor genistein significantly blocked the TNF effect. Genistein tumor necrosis factor Homo sapiens
2 After the tight junctions have opened at 2 h in response to TNF, a second application of TNF will not produce the effect again for at least 12 h. The tight junctions will, however, open in response to phorbol esters during this time frame. Phorbol Esters tumor necrosis factor Homo sapiens
3 Electron microscopy studies using apically applied ruthenium red suggest that TNF action results in < 10% of the junctions having increased permeability at any given time during the resistance decrease. Ruthenium Red tumor necrosis factor Homo sapiens