Title : Human uridine diphosphate-glucuronosyltransferase UGT2B7 conjugates mineralocorticoid and glucocorticoid metabolites.

Pub. Date : 2003 Jun

PMID : 12746330






2 Functional Relationships(s)
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1 Kinetic analyses reveal that UGT2B7 polymorphisms glucuronidate mineralocorticoids with a 5.5- to 20-fold higher affinity than glucocorticoids. glucuronidate UDP glucuronosyltransferase family 2 member B7 Homo sapiens
2 For the first time, a significant difference between the two allelic variants of UGT2B7 is described, because UGT2B7H((268)) possesses an 11-fold higher aldosterone glucuronidation efficiency (ratio Vmax((app.))/Km((app.))) Aldosterone UDP glucuronosyltransferase family 2 member B7 Homo sapiens