Pub. Date : 2003 Apr
PMID : 12703986
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [8-Chloro-adenosine increases the activity of transcription factor CREB by modification of phosphorylation]. | 8-chloroadenosine | cAMP responsive element binding protein 1 | Homo sapiens |
| 2 | This study was conducted to investigate the effect of 8-Cl-Ado on the activity of transcription factor cAMP-response-element-binding protein(CREB) and its correlative mechanism in human promyelocytic leukemia cell line HL-60. | 8-chloroadenosine | cAMP responsive element binding protein 1 | Homo sapiens |
| 3 | The protein levels and phosphorylated levels of CREB at different time following 8-Cl-Ado stimulation were examined using Western blot analysis. | 8-chloroadenosine | cAMP responsive element binding protein 1 | Homo sapiens |
| 4 | Gel shift assay was performed to examine DNA binding levels of CREB at different time following 8-Cl-Ado stimulation. | 8-chloroadenosine | cAMP responsive element binding protein 1 | Homo sapiens |
| 5 | (2)8-Cl-Ado increased phosphorylated level of CREB rapidly, which was maximal at 30 minutes, and returned to basal level in 6 hours. | 8-chloroadenosine | cAMP responsive element binding protein 1 | Homo sapiens |
| 6 | The protein level of CREB was constant during 8-Cl-Ado stimulation. | 8-chloroadenosine | cAMP responsive element binding protein 1 | Homo sapiens |
| 7 | CONCLUSION: The increase of transcriptional activity of CREB induced by 8-Cl-Ado depends on the increased level of phosphorylated CREB, but is not associated with the protein level and DNA binging level of CREB. | 8-chloroadenosine | cAMP responsive element binding protein 1 | Homo sapiens |
| 8 | CONCLUSION: The increase of transcriptional activity of CREB induced by 8-Cl-Ado depends on the increased level of phosphorylated CREB, but is not associated with the protein level and DNA binging level of CREB. | 8-chloroadenosine | cAMP responsive element binding protein 1 | Homo sapiens |
| 9 | CONCLUSION: The increase of transcriptional activity of CREB induced by 8-Cl-Ado depends on the increased level of phosphorylated CREB, but is not associated with the protein level and DNA binging level of CREB. | 8-chloroadenosine | cAMP responsive element binding protein 1 | Homo sapiens |