Title : Role of redox signaling in the autonomous proliferative response of endothelial cells to hypoxia.

Pub. Date : 2003 May 16

PMID : 12690038






2 Functional Relationships(s)
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1 To inhibit the MEK/ERK pathway, we used PD 98059 (PD, 20 micromol/L); to downregulate NAD(P)H oxidase, we applied p22phox antisense oligonucleotides; and to inhibit mitochondrial ROS generation, we used the ubiquinone derivate mitoQ (MQ, 10 micromol/L). Oligonucleotides cytochrome b-245 alpha chain Homo sapiens
2 All three inhibitions suppressed the proliferative response: PD inhibited NAD(P)H oxidase activation; p22phox antisense transfection did not inhibit ERK2 activation, but suppressed ROS production; and MQ inhibited ERK2 activation and ROS production. Reactive Oxygen Species cytochrome b-245 alpha chain Homo sapiens