Pub. Date : 2003 May
PMID : 12657745
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glucuronidation of 1"-hydroxyestragole (1"-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9. | 1'-hydroxyestragole | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 2 | Glucuronidation of 1"-hydroxyestragole (1"-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9. | 1'-hydroxyestragole | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 3 | 1"-HE glucuronidation in 27 individual human liver samples significantly (p < 0.05) correlated with the glucuronidation of other UGT2B7 substrates (morphine and ibuprofen). | Morphine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 4 | 1"-HE glucuronidation in 27 individual human liver samples significantly (p < 0.05) correlated with the glucuronidation of other UGT2B7 substrates (morphine and ibuprofen). | Ibuprofen | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 5 | These results imply that concomitant chronic intake of therapeutic drugs and dietary components that are UGT2B7 and/or UGT1A9 substrates may interfere with estragole metabolism. | estragole | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 6 | Our results also have toxicogenetic significance, as UGT2B7 is polymorphic and could potentially result in genetic differences in glucuronidation of 1"-HE and, hence, toxicity of estragole. | estragole | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |