Pub. Date : 2002 Dec 27
PMID : 12515593
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SKF 525A, which inhibits CYP2B, CYP2C11, and CYP3A2, and orphenadrine, which inhibits CYP2B, also decreased MA(2) formation in liver microsomes from 7-wk-old phenobarbital-pretreated rats. | Proadifen | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
| 2 | Furthermore, an immunoinhibition study demonstrated that anti-CYP3A2 antibody reduced MA(1), MAX, and MA(2) formation to nondetectable levels in liver microsomes from 2- and 7-wk-old rats, whereas anti-CYP2C11 or anti-CYP2B antibody, respectively, had no marked effect on MA(1), MAX, and MA(2) formation in liver microsomes from 7-wk-old untreated or PB-treated rats. | Phenobarbital | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |