Title : Differential induction of midazolam metabolism in the small intestine and liver by oral and intravenous dexamethasone pretreatment in rat.

Pub. Date : 2002 Nov

PMID : 12487727






2 Functional Relationships(s)
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1 CYP3A1 and CYP3A2 protein levels in liver microsomes were significantly increased following oral (3.7- and 3.2-fold, respectively) or intravenous (2.6- and 2.1-fold, respectively) pretreatment with dexamethasone. Dexamethasone cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
2 On the contrary, only oral dexamethasone pretreatment resulted in a significant change in intestinal CYP3A2-like protein (7.3-fold). Dexamethasone cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus