Title : Activation of A-type gamma-aminobutyric acid receptors excites gonadotropin-releasing hormone neurons.

Pub. Date : 2002 Dec

PMID : 12456806






7 Functional Relationships(s)
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1 Gamma-aminobutyric acid (GABA), acting through GABA(A) receptors (GABA(A)R), is hypothesized to suppress reproduction by inhibiting GnRH secretion, but GABA actions directly on GnRH neurons are not well established. gamma-Aminobutyric Acid gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
2 Gamma-aminobutyric acid (GABA), acting through GABA(A) receptors (GABA(A)R), is hypothesized to suppress reproduction by inhibiting GnRH secretion, but GABA actions directly on GnRH neurons are not well established. gamma-Aminobutyric Acid gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
3 Gamma-aminobutyric acid (GABA), acting through GABA(A) receptors (GABA(A)R), is hypothesized to suppress reproduction by inhibiting GnRH secretion, but GABA actions directly on GnRH neurons are not well established. gamma-Aminobutyric Acid gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
4 Gamma-aminobutyric acid (GABA), acting through GABA(A) receptors (GABA(A)R), is hypothesized to suppress reproduction by inhibiting GnRH secretion, but GABA actions directly on GnRH neurons are not well established. gamma-Aminobutyric Acid gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
5 Gamma-aminobutyric acid (GABA), acting through GABA(A) receptors (GABA(A)R), is hypothesized to suppress reproduction by inhibiting GnRH secretion, but GABA actions directly on GnRH neurons are not well established. gamma-Aminobutyric Acid gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
6 The consequence of GABA(A)R activation depends on intracellular chloride levels, which are maintained by homeostatic mechanisms. Chlorides gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
7 In contrast, bath application of the GABA(A)R agonist muscimol transiently increased then suppressed firing; suppression persisted 4-15 min. Muscimol gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus