Title : Activation of vascular cells by PAF-like lipids in oxidized LDL.

Pub. Date : 2002 Apr

PMID : 12449015






7 Functional Relationships(s)
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Protein Name
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1 The PAFR recognizes the short residue, an acetate residue, at the 2-position of the phospholipid, and this sharp specificity precludes receptor activation by other related phosphatidylcholines. Acetates platelet activating factor receptor Homo sapiens
2 The PAFR recognizes the short residue, an acetate residue, at the 2-position of the phospholipid, and this sharp specificity precludes receptor activation by other related phosphatidylcholines. Phospholipids platelet activating factor receptor Homo sapiens
3 The PAFR recognizes the short residue, an acetate residue, at the 2-position of the phospholipid, and this sharp specificity precludes receptor activation by other related phosphatidylcholines. Phosphatidylcholines platelet activating factor receptor Homo sapiens
4 Oxidation of LDLs fragments and derivatizes the fatty acid residues at the 2-position of the phosphatidylcholines that comprise the shell of LDLs, an event that allows certain oxidized phospholipids to interact with and activate the PAFR. Fatty Acids platelet activating factor receptor Homo sapiens
5 Oxidation of LDLs fragments and derivatizes the fatty acid residues at the 2-position of the phosphatidylcholines that comprise the shell of LDLs, an event that allows certain oxidized phospholipids to interact with and activate the PAFR. Phosphatidylcholines platelet activating factor receptor Homo sapiens
6 Oxidation of LDLs fragments and derivatizes the fatty acid residues at the 2-position of the phosphatidylcholines that comprise the shell of LDLs, an event that allows certain oxidized phospholipids to interact with and activate the PAFR. Phospholipids platelet activating factor receptor Homo sapiens
7 Here, we show that PAF-like lipids from oxidized LDLs are potent and serve as specific agonists for all cells that express the PAFR. Platelet Activating Factor platelet activating factor receptor Homo sapiens