Pub. Date : 2002 Aug
PMID : 12435857
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The gene associated with Rogers syndrome encodes for a plasma membrane thiamine transporter, THTR-1, a member of the solute carrier family that includes its homologue THTR-2 and the reduced folate carrier. | Folic Acid | solute carrier family 19 member 2 | Homo sapiens |
| 2 | The transport activity of the transfected THTR-1 proteins was measured using a [(3) H] thiamine uptake assay. | Thiamine | solute carrier family 19 member 2 | Homo sapiens |
| 3 | In contrast to its fully glycosylated wild-type mature protein, the mutant THTR-1 protein underwent only the initial stage of N-linked glycosylation. | Nitrogen | solute carrier family 19 member 2 | Homo sapiens |
| 4 | Finally, transfection studies revealed that the mutant G172D THTR-1 failed to transport thiamine. | Thiamine | solute carrier family 19 member 2 | Homo sapiens |