Title : Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy.

Pub. Date : 2002 Aug

PMID : 12185559






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 OBJECTIVE: UDP-glucuronosyltransferase (UGT) 2B7 is the major UGT isoform responsible for the 3- and 6-glucuronidation of morphine in humans. Morphine UDP glucuronosyltransferase family 2 member B7 Homo sapiens
2 Our objective was to investigate whether the UGT2B7 H268Y and UGT1A1*28 polymorphisms contribute to the variability in morphine glucuronide-to-morphine plasma ratios among cancer patients undergoing analgesic therapy with morphine. Morphine UDP glucuronosyltransferase family 2 member B7 Homo sapiens
3 Our objective was to investigate whether the UGT2B7 H268Y and UGT1A1*28 polymorphisms contribute to the variability in morphine glucuronide-to-morphine plasma ratios among cancer patients undergoing analgesic therapy with morphine. Glucuronides UDP glucuronosyltransferase family 2 member B7 Homo sapiens
4 Our objective was to investigate whether the UGT2B7 H268Y and UGT1A1*28 polymorphisms contribute to the variability in morphine glucuronide-to-morphine plasma ratios among cancer patients undergoing analgesic therapy with morphine. Morphine UDP glucuronosyltransferase family 2 member B7 Homo sapiens
5 Our objective was to investigate whether the UGT2B7 H268Y and UGT1A1*28 polymorphisms contribute to the variability in morphine glucuronide-to-morphine plasma ratios among cancer patients undergoing analgesic therapy with morphine. Morphine UDP glucuronosyltransferase family 2 member B7 Homo sapiens