Title : Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases.

Pub. Date : 2002 Sep

PMID : 12167566






4 Functional Relationships(s)
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Protein Name
Organism
1 Alpha-DHA-G was formed in incubations of DHA with expressed UGT1A9 (K(m) 32 microM, V(max) 8.9 pmol min(-1) mg(-1)) or UGT2B7 (K(m) 438 microM, V(max) 10.9 pmol mg(-1) min(-1)) but not with UGT1A1 or UGT1A6. alpha-dha-g UDP glucuronosyltransferase family 2 member B7 Homo sapiens
2 Alpha-DHA-G was formed in incubations of DHA with expressed UGT1A9 (K(m) 32 microM, V(max) 8.9 pmol min(-1) mg(-1)) or UGT2B7 (K(m) 438 microM, V(max) 10.9 pmol mg(-1) min(-1)) but not with UGT1A1 or UGT1A6. artenimol UDP glucuronosyltransferase family 2 member B7 Homo sapiens
3 We conclude that alpha-DHA-G is an important metabolite of DHA in humans and that its formation is catalyzed by UGT1A9 and UGT2B7. alpha-dha-g UDP glucuronosyltransferase family 2 member B7 Homo sapiens
4 We conclude that alpha-DHA-G is an important metabolite of DHA in humans and that its formation is catalyzed by UGT1A9 and UGT2B7. artenimol UDP glucuronosyltransferase family 2 member B7 Homo sapiens