Pub. Date : 2002 Sep 6
PMID : 12084721
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FGF3 attached to a phosholipid membrane anchor gains a high transforming capacity. | phosholipid | fibroblast growth factor 3 | Mus musculus |
| 2 | Heparin or heparan sulfate displaces FGF3 from binding sites on the cell surface inhibiting the growth of DMI cells and reverts the transformed phenotype (). | Heparin | fibroblast growth factor 3 | Mus musculus |
| 3 | Heparin or heparan sulfate displaces FGF3 from binding sites on the cell surface inhibiting the growth of DMI cells and reverts the transformed phenotype (). | Heparitin Sulfate | fibroblast growth factor 3 | Mus musculus |
| 4 | Heparin or heparan sulfate displaces FGF3 from binding sites on the cell surface inhibiting the growth of DMI cells and reverts the transformed phenotype (). | Desipramine | fibroblast growth factor 3 | Mus musculus |
| 5 | However, the presence of heparin is necessary to induce a mitogenic response in NIH3T3 cells when stimulated with soluble purified mouse FGF3. | Heparin | fibroblast growth factor 3 | Mus musculus |
| 6 | We have investigated the importance of cell surface binding of FGF3 for its ability to transform NIH3T3 cells by creating an FGF3 mutant anchored to the membrane via glycosylphosphatidylinositol (GPI). | Glycosylphosphatidylinositols | fibroblast growth factor 3 | Mus musculus |
| 7 | We have investigated the importance of cell surface binding of FGF3 for its ability to transform NIH3T3 cells by creating an FGF3 mutant anchored to the membrane via glycosylphosphatidylinositol (GPI). | Glycosylphosphatidylinositols | fibroblast growth factor 3 | Mus musculus |
| 8 | We have investigated the importance of cell surface binding of FGF3 for its ability to transform NIH3T3 cells by creating an FGF3 mutant anchored to the membrane via glycosylphosphatidylinositol (GPI). | Glycosylphosphatidylinositols | fibroblast growth factor 3 | Mus musculus |
| 9 | Because NIH3T3 cells do not express the high affinity tyrosine kinase FGF receptors for FGF3, these findings suggest that FGF3 attached to GPI-linked heparan sulfate-proteoglycan may have a broader biological activity as when bound to transmembrane or soluble heparan sulfate-proteoglycan. | Glycosylphosphatidylinositols | fibroblast growth factor 3 | Mus musculus |
| 10 | Because NIH3T3 cells do not express the high affinity tyrosine kinase FGF receptors for FGF3, these findings suggest that FGF3 attached to GPI-linked heparan sulfate-proteoglycan may have a broader biological activity as when bound to transmembrane or soluble heparan sulfate-proteoglycan. | Heparitin Sulfate | fibroblast growth factor 3 | Mus musculus |
| 11 | Because NIH3T3 cells do not express the high affinity tyrosine kinase FGF receptors for FGF3, these findings suggest that FGF3 attached to GPI-linked heparan sulfate-proteoglycan may have a broader biological activity as when bound to transmembrane or soluble heparan sulfate-proteoglycan. | Heparitin Sulfate | fibroblast growth factor 3 | Mus musculus |