Pub. Date : 2002 Feb 15
PMID : 11992633
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine, a potent inhibitor of cAMP-specific phosphodiesterase, enhancing nuclear protein binding to the CRE consensus sequence in human tumour cells. | 8-chloro-cyclic adenosine monophosphate | regulating synaptic membrane exocytosis 2 | Homo sapiens |
| 2 | The cAMP-specific phosphodiesterase isoenzyme family PDE4 represents the highest cAMP-hydrolysing activity in many human cancer cell lines including the human large cell lung carcinoma cell line LXFL529L. | 8-chloro-cyclic adenosine monophosphate | phosphodiesterase 4A | Homo sapiens |
| 3 | The cAMP-specific phosphodiesterase isoenzyme family PDE4 represents the highest cAMP-hydrolysing activity in many human cancer cell lines including the human large cell lung carcinoma cell line LXFL529L. | 8-chloro-cyclic adenosine monophosphate | phosphodiesterase 4A | Homo sapiens |
| 4 | DC-TA-46 mediated inhibition of PDE4 activity in LXFL529L cells resulted in an increase of the intracellular cAMP level and significant induction of the activity of protein kinase A (PKA). | 8-chloro-cyclic adenosine monophosphate | phosphodiesterase 4A | Homo sapiens |