Title : Effects of phenothiazine neuroleptics on the rate of caffeine demethylation and hydroxylation in the rat liver.

Pub. Date : 2001 Nov-Dec

PMID : 11985335






2 Functional Relationships(s)
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1 The isoenzymes CYP1A2 and CYP3A2 were distinctly inhibited by all the investigated neuroleptics, while other CYP isoenzymes (CYP2B and/or 2E1) by perazine and levomepromazine. Perazine cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
2 The isoenzymes CYP1A2 and CYP3A2 were distinctly inhibited by all the investigated neuroleptics, while other CYP isoenzymes (CYP2B and/or 2E1) by perazine and levomepromazine. Methotrimeprazine cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus