Title : Bioavailability and efficacy of antisense morpholino oligomers targeted to c-myc and cytochrome P-450 3A2 following oral administration in rats.

Pub. Date : 2002 Apr

PMID : 11948540






2 Functional Relationships(s)
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1 The CYP3A2 antisense 22-mer AVI-4472 (5"-GAGCTGAAAGCAGGTCCATCCC-3") caused a sequence-dependent reduction of approximately five-fold in the rat liver CYP3A2 protein levels and erythromycin demethylation activity in 24 h following oral administration at a dose of 2 mg/kg. Erythromycin cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
2 It is concluded that oral administration of PMOs can inhibit c-myc and CYP3A2 gene expression in rat liver by an antisense-based mechanism of action. pmos cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus