Title : Denervation supersensitivity in the cholinergic septo-hippocampal pathway: a microiontophoretic study.

Pub. Date : 1975 Dec 19

PMID : 1192181






5 Functional Relationships(s)
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1 A time course for the development of ACh supersensitivity was found to be similar to the time course of AChE loss previosly reported. Acetylcholine acetylcholinesterase Rattus norvegicus
2 Experiments using physostigmine, an AChE inhibitor, demonstrated that inhibition of AChE can potentiate the effects of ACh in unlesioned preparations, but not in lesioned preparations. Physostigmine acetylcholinesterase Rattus norvegicus
3 Experiments using physostigmine, an AChE inhibitor, demonstrated that inhibition of AChE can potentiate the effects of ACh in unlesioned preparations, but not in lesioned preparations. Physostigmine acetylcholinesterase Rattus norvegicus
4 Experiments using physostigmine, an AChE inhibitor, demonstrated that inhibition of AChE can potentiate the effects of ACh in unlesioned preparations, but not in lesioned preparations. Acetylcholine acetylcholinesterase Rattus norvegicus
5 We conclude: (1) denervation supersensitivity to ACh occurs in the septo-hippocampal pathway; and (2) the supersensitivity is probably due to decreased inactivation of ACh by AChE. Acetylcholine acetylcholinesterase Rattus norvegicus