CPRiL

3 Functional Relationships(s) Download
	Sentence	Compound Name	Protein Name	Organism
1	On the other hand, the gene expression of CYP3A2 and flavin-containing monooxygenase 1 (FMO1), responsible for the N-demethylation and N-oxidation, respectively, of tamoxifen was increased in a time-dependent fashion up to the 52 week treatment.	Tamoxifen	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus
2	The present findings demonstrate that in the early stage of the formation of the liver hyperplastic nodules by tamoxifen, the genes of the enzymes responsible for not only detoxification but also activation of tamoxifen were activated, whereas in the later stage (in the nodules), the genes of the detoxification enzymes, CYP3A2 and FMO1, remained active, but those of the activation enzymes such as CYP3A1 and HSTa were suppressed.	Tamoxifen	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus
3	The present findings demonstrate that in the early stage of the formation of the liver hyperplastic nodules by tamoxifen, the genes of the enzymes responsible for not only detoxification but also activation of tamoxifen were activated, whereas in the later stage (in the nodules), the genes of the detoxification enzymes, CYP3A2 and FMO1, remained active, but those of the activation enzymes such as CYP3A1 and HSTa were suppressed.	Tamoxifen	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus