Pub. Date : 2002 Mar
PMID : 11875010
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: The preincubation of microsomes with indomethacin and reduced nicotinamide adenine dinucleotide phosphate decreased CYP3A2 activity but not any other isoforms. | Indomethacin | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
| 2 | RESULTS: The preincubation of microsomes with indomethacin and reduced nicotinamide adenine dinucleotide phosphate decreased CYP3A2 activity but not any other isoforms. | NADP | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
| 3 | Administration of indomethacin caused impairment of not only CYP3A2 but also other CYP isoforms. | Indomethacin | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
| 4 | CONCLUSIONS: Metabolism of indomethacin causes inactivation of CYP3A2, which is the result of the covalent binding of its metabolite, whereas partially selective in vivo impairment of CYP isoforms is suggested to be indirect inhibition by inflammatory mediators probably released from Kupffer cells. | Indomethacin | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |