Title : Increased activity of CYP3A enzyme in primary cultures of rat hepatocytes treated with docetaxel: comparative evaluation with paclitaxel.

Pub. Date : 2001 Aug

PMID : 11561777






2 Functional Relationships(s)
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1 The metabolism of docetaxel to its primary metabolite, hydroxydocetaxel, is mediated by cytochrome P450 isozymes CYP3A2 and CYP3A4 in rats and humans, respectively. Docetaxel cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
2 The metabolism of docetaxel to its primary metabolite, hydroxydocetaxel, is mediated by cytochrome P450 isozymes CYP3A2 and CYP3A4 in rats and humans, respectively. hydroxydocetaxel cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus