Title : Retrovirus-mediated expression of the base excision repair proteins, formamidopyrimidine DNA glycosylase or human oxoguanine DNA glycosylase, protects hematopoietic cells from N,N',N"-triethylenethiophosphoramide (thioTEPA)-induced toxicity in vitro and in vivo.

Pub. Date : 2001 Jul 1

PMID : 11431349






2 Functional Relationships(s)
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Protein Name
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1 These results show that expression of the Fpg or hOGG1 protein protects hematopoietic cells from thioTEPA-induced DNA damage and suggest that a high level of expression of these repair proteins is required to establish resistance to this drug. Thiotepa 8-oxoguanine DNA glycosylase Homo sapiens
2 Expression of Fpg and/or OGG1 may provide an novel approach to preventing thioTEPA-induced toxicity of primary hematopoietic cells. Thiotepa 8-oxoguanine DNA-glycosylase 1 Mus musculus