Title : Overexpressed human RAD50 exhibits cell death in a p21(WAF1/CIP1)-dependent manner: its potential utility in local gene therapy of tumor.

Pub. Date : 2001 May

PMID : 11373271






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We established tetracycline-regulated, stable hRAD50 expression systems in SaOS-2 cells, which retain mutated p53, and in HeLa cells. Tetracycline RAD50 double strand break repair protein Homo sapiens
2 After tetracycline withdrawal, cell death and multinucleated giant cells were observed with increased hRAD50 expression, and p21(WAF1/CIP1) but not p53 was increased. Tetracycline RAD50 double strand break repair protein Homo sapiens
3 These cytotoxic effects of overexpressed hRAD50 in HeLa, SaOS-2, and HCT116 p21(+/+) cells were partially blocked by pretreatment of cells with N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone, a pan-caspase inhibitor. Caspase Inhibitor VI RAD50 double strand break repair protein Homo sapiens