Pub. Date : 2001 May
PMID : 11373271
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We established tetracycline-regulated, stable hRAD50 expression systems in SaOS-2 cells, which retain mutated p53, and in HeLa cells. | Tetracycline | RAD50 double strand break repair protein | Homo sapiens |
2 | After tetracycline withdrawal, cell death and multinucleated giant cells were observed with increased hRAD50 expression, and p21(WAF1/CIP1) but not p53 was increased. | Tetracycline | RAD50 double strand break repair protein | Homo sapiens |
3 | These cytotoxic effects of overexpressed hRAD50 in HeLa, SaOS-2, and HCT116 p21(+/+) cells were partially blocked by pretreatment of cells with N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone, a pan-caspase inhibitor. | Caspase Inhibitor VI | RAD50 double strand break repair protein | Homo sapiens |