Title : Protective effects of coffee diterpenes against aflatoxin B1-induced genotoxicity: mechanisms in rat and human cells.

Pub. Date : 2001 Jun

PMID : 11346484






2 Functional Relationships(s)
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1 In rat primary hepatocytes, C + K reduced the expression of cytochrome P450 CYP 2C11 and CYP 3A2, the key enzymes responsible for AFB1 activation to the genotoxic metabolite aflatoxin B1-8,9 epoxide (AFBO). Aflatoxin B1 cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
2 In rat primary hepatocytes, C + K reduced the expression of cytochrome P450 CYP 2C11 and CYP 3A2, the key enzymes responsible for AFB1 activation to the genotoxic metabolite aflatoxin B1-8,9 epoxide (AFBO). aflatoxin B1-2,3-oxide cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus