Pub. Date : 2001 May
PMID : 11294973
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Conversely, human UGT2B7 displayed a high rate of diclofenac glucuronide formation (>500 pmol/min/mg protein). | 1-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 2 | Morphine is a known substrate for rat UGT2B1 and human UGT2B7 and both total morphine glucuronidation (3-O- and 6-O-glucuronides) and diclofenac glucuronidation reactions showed a strong correlation with one another in human liver microsome samples. | Morphine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 3 | These data suggested that rat UGT2B1 and human UGT2B7 were the major UGT isoforms involved in the glucuronidation of diclofenac. | Diclofenac | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |