Title : Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver.

Pub. Date : 2001 Apr

PMID : 11290831






2 Functional Relationships(s)
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1 We found that oxidatively modified phosphatidylcholines were present in the livers of CCl4-exposed rats and not in livers from control animals, that CCl4 metabolism generated lipids that activated 293 cells stably transfected with the human platelet-activating factor (PAF) receptor, and that this PAF-like activity was formed as rapidly as isoprostane-containing phosphatidylcholine (iPC) during oxidation. Phosphatidylcholines platelet activating factor receptor Homo sapiens
2 We found that oxidatively modified phosphatidylcholines were present in the livers of CCl4-exposed rats and not in livers from control animals, that CCl4 metabolism generated lipids that activated 293 cells stably transfected with the human platelet-activating factor (PAF) receptor, and that this PAF-like activity was formed as rapidly as isoprostane-containing phosphatidylcholine (iPC) during oxidation. Phosphatidylcholines platelet activating factor receptor Homo sapiens