Title : Transdermal delivery of antisense oligonucleotides can induce changes in gene expression in vivo.

Pub. Date : 2001 Feb

PMID : 11258617






7 Functional Relationships(s)
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1 A C5 propyne-modified phosphorothioate oligonucleotide (PS-ODN) targeted to the cytochrome p450-3A2 (CYP3A2) mRNA translational start site and the reverse sequence, used as a control, were synthesized. methylacetylene cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
2 A C5 propyne-modified phosphorothioate oligonucleotide (PS-ODN) targeted to the cytochrome p450-3A2 (CYP3A2) mRNA translational start site and the reverse sequence, used as a control, were synthesized. methylacetylene cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
3 A C5 propyne-modified phosphorothioate oligonucleotide (PS-ODN) targeted to the cytochrome p450-3A2 (CYP3A2) mRNA translational start site and the reverse sequence, used as a control, were synthesized. Phosphorothioate Oligonucleotides cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
4 A C5 propyne-modified phosphorothioate oligonucleotide (PS-ODN) targeted to the cytochrome p450-3A2 (CYP3A2) mRNA translational start site and the reverse sequence, used as a control, were synthesized. Phosphorothioate Oligonucleotides cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
5 A C5 propyne-modified phosphorothioate oligonucleotide (PS-ODN) targeted to the cytochrome p450-3A2 (CYP3A2) mRNA translational start site and the reverse sequence, used as a control, were synthesized. ps-odn cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
6 A C5 propyne-modified phosphorothioate oligonucleotide (PS-ODN) targeted to the cytochrome p450-3A2 (CYP3A2) mRNA translational start site and the reverse sequence, used as a control, were synthesized. ps-odn cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
7 Midozolam-treated animals with antisense to CYP3A2 slept significantly longer than did the controls (p < 0.05). midozolam cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus