Pub. Date : 2001 Feb 19
PMID : 11223159
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glatiramer acetate blocks interleukin-1-dependent nuclear factor-kappaB activation and RANTES expression in human U-251 MG astroglial cells. | Glatiramer Acetate | C-C motif chemokine ligand 5 | Homo sapiens |
| 2 | Glatiramer acetate is a drug recently approved for the treatment of MS. We therefore investigated the effect of glatiramer acetate on RANTES expression in glial cells in vitro. | Glatiramer Acetate | C-C motif chemokine ligand 5 | Homo sapiens |
| 3 | Treatment of human U-251 MG astroglial cells with glatiramer acetate blocks IL-1beta-induced RANTES chemokine production in a dose- and time-dependent manner. | Glatiramer Acetate | interleukin 1 beta | Homo sapiens |
| 4 | Treatment of human U-251 MG astroglial cells with glatiramer acetate blocks IL-1beta-induced RANTES chemokine production in a dose- and time-dependent manner. | Glatiramer Acetate | C-C motif chemokine ligand 5 | Homo sapiens |
| 5 | Glatiramer acetate also decreased steady-state levels of RANTES mRNA in these cells, which was attributable to reduced transcription, as assessed by nuclear run-on assays. | Glatiramer Acetate | C-C motif chemokine ligand 5 | Homo sapiens |
| 6 | Furthermore, we demonstrated that the increase in NF-kappaB DNA-binding activity was prevented by pretreatment with glatiramer acetate or the NF-kappaB inhibitors. | Glatiramer Acetate | nuclear factor kappa B subunit 1 | Homo sapiens |
| 7 | Our results suggest that glatiramer acetate may inhibit IL-1beta-stimulated RANTES expression in human glial cells by blocking NF-kappaB activation, thus identifying part of the molecular basis for its anti-inflammatory and immunosuppressive effects in demyelinating diseases. | Glatiramer Acetate | interleukin 1 beta | Homo sapiens |
| 8 | Our results suggest that glatiramer acetate may inhibit IL-1beta-stimulated RANTES expression in human glial cells by blocking NF-kappaB activation, thus identifying part of the molecular basis for its anti-inflammatory and immunosuppressive effects in demyelinating diseases. | Glatiramer Acetate | C-C motif chemokine ligand 5 | Homo sapiens |
| 9 | Our results suggest that glatiramer acetate may inhibit IL-1beta-stimulated RANTES expression in human glial cells by blocking NF-kappaB activation, thus identifying part of the molecular basis for its anti-inflammatory and immunosuppressive effects in demyelinating diseases. | Glatiramer Acetate | nuclear factor kappa B subunit 1 | Homo sapiens |