Title : Allelic variation in the GABA A receptor gamma2 subunit is associated with genetic susceptibility to ethanol-induced motor incoordination and hypothermia, conditioned taste aversion, and withdrawal in BXD/Ty recombinant inbred mice.

Pub. Date : 2000 Sep

PMID : 11003197






7 Functional Relationships(s)
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1 We analyzed genetic correlations between allelic variation in Gabrg2 and alcohol phenotypes previously measured in the BXD strain means. Alcohols gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
2 RESULTS: Allelic variation in Gabrg2 is correlated genetically with predisposition to acute alcohol withdrawal and may underlie the Alcw3 locus. Alcohols gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
3 In addition, Gabrg2 is associated with ethanol-conditioned taste aversion, ethanol-induced motor incoordination, and ethanol-induced hypothermia. Ethanol gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
4 In addition, Gabrg2 is associated with ethanol-conditioned taste aversion, ethanol-induced motor incoordination, and ethanol-induced hypothermia. Ethanol gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
5 In addition, Gabrg2 is associated with ethanol-conditioned taste aversion, ethanol-induced motor incoordination, and ethanol-induced hypothermia. Ethanol gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
6 CONCLUSIONS: Functionally relevant variation in Gabrg2, or a closely linked gene, is correlated genetically with some, but not all, behavioral responses to alcohol. Alcohols gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
7 The alcohol-related phenotypes associated with Gabrg2 generally may be characterized as debilitating or motivationally negative. Alcohols gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus