Title : Self-augmentation effect of male-specific products on sexually differentiated progesterone metabolism in adult male rat liver microsomes.

Pub. Date : 2001 Feb 16

PMID : 10995741






3 Functional Relationships(s)
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1 In the male, these steroids are primarily metabolized into two oxidized (16alpha-hydroxyl and 6beta-hydroxyl) products mainly by the respective, male-specific cytochrome P450 subforms, CYP2C11 and CYP3A2, while they are primarily metabolized into the 5alpha-reduced products by female-predominant 5alpha-reductase in the female. Steroids cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
2 In the male, these steroids are primarily metabolized into two oxidized (16alpha-hydroxyl and 6beta-hydroxyl) products mainly by the respective, male-specific cytochrome P450 subforms, CYP2C11 and CYP3A2, while they are primarily metabolized into the 5alpha-reduced products by female-predominant 5alpha-reductase in the female. 16alpha-hydroxyl cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
3 In the male, these steroids are primarily metabolized into two oxidized (16alpha-hydroxyl and 6beta-hydroxyl) products mainly by the respective, male-specific cytochrome P450 subforms, CYP2C11 and CYP3A2, while they are primarily metabolized into the 5alpha-reduced products by female-predominant 5alpha-reductase in the female. 6beta-hydroxyl cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus