Pub. Date : 2000 Jun
PMID : 10820138
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In humans, morphine is known to undergo extensive metabolism by glucuronidation, and the UDP-glucuronosyltransferase isoform, which catalyzes the formation of morphine-3-O-glucuronide and morphine-6-O-glucuronide is UGT2B7. | Morphine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 2 | In humans, morphine is known to undergo extensive metabolism by glucuronidation, and the UDP-glucuronosyltransferase isoform, which catalyzes the formation of morphine-3-O-glucuronide and morphine-6-O-glucuronide is UGT2B7. | morphine-3-o-glucuronide | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 3 | In humans, morphine is known to undergo extensive metabolism by glucuronidation, and the UDP-glucuronosyltransferase isoform, which catalyzes the formation of morphine-3-O-glucuronide and morphine-6-O-glucuronide is UGT2B7. | morphine-6-o-glucuronide | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 4 | The K(m) of morphine using beagle dog liver microsomes was approximately 270 microM, which is similar to that found for expressed human UGT2B7. | Morphine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 5 | Flunitrazepam inhibited the glucuronidation of morphine in dog liver microsomes, and the K(i) was 40 microM, which is similar to human UGT2B7 for other substrates. | Flunitrazepam | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 6 | Flunitrazepam inhibited the glucuronidation of morphine in dog liver microsomes, and the K(i) was 40 microM, which is similar to human UGT2B7 for other substrates. | Morphine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |