Title : Glucose degradation product methylglyoxal enhances the production of vascular endothelial growth factor in peritoneal cells: role in the functional and morphological alterations of peritoneal membranes in peritoneal dialysis.

Pub. Date : 1999 Dec 17

PMID : 10606733






3 Functional Relationships(s)
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1 We test whether glucose degradation products (GDPs) in PD fluids, glyoxal, methylglyoxal and 3-deoxyglucosone, stimulate the production of vascular endothelial growth factor (VEGF), a factor known to enhance vascular permeability and angiogenesis. Pyruvaldehyde vascular endothelial growth factor A Homo sapiens
2 We test whether glucose degradation products (GDPs) in PD fluids, glyoxal, methylglyoxal and 3-deoxyglucosone, stimulate the production of vascular endothelial growth factor (VEGF), a factor known to enhance vascular permeability and angiogenesis. Pyruvaldehyde vascular endothelial growth factor A Homo sapiens
3 VEGF increased in cultured rat mesothelial and human endothelial cells exposed to methylglyoxal, but not to glyoxal or 3-deoxyglucosone. Pyruvaldehyde vascular endothelial growth factor A Rattus norvegicus