Pub. Date : 1999 Dec
PMID : 10565810
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Microsomal androst-4-ene-3,17-dione hydroxylation activities mediated by CYP2C11 (16alpha-hydroxylation) and CYP3A2 (6beta-hydroxylation) were decreased in liver from OA-fed rats for only 5 days, whereas CYP2A1/2-mediated steroid 7alpha-hydroxylation was decreased after 10 days; these observations were complemented by immunoblot analysis that demonstrated the impaired expression of the corresponding CYP proteins. | Androstenedione | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
2 | Microsomal androst-4-ene-3,17-dione hydroxylation activities mediated by CYP2C11 (16alpha-hydroxylation) and CYP3A2 (6beta-hydroxylation) were decreased in liver from OA-fed rats for only 5 days, whereas CYP2A1/2-mediated steroid 7alpha-hydroxylation was decreased after 10 days; these observations were complemented by immunoblot analysis that demonstrated the impaired expression of the corresponding CYP proteins. | Steroids | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |