Title : Cytochrome CYP sources of N-alkylprotoporphyrin IX after administration of porphyrinogenic xenobiotics to rats.

Pub. Date : 1999 Sep

PMID : 10460791






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cytochrome P-450 (CYP) 3A2 and CYP2C11 are sources of 70 and 30%, respectively, of N-vinylprotoporphyrin IX (N-vinylPP) formation after administration of 3-[(arylthio)ethyl]sydnone (TTMS) to rats. 21-Vinylprotoporphyrin cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
2 Cytochrome P-450 (CYP) 3A2 and CYP2C11 are sources of 70 and 30%, respectively, of N-vinylprotoporphyrin IX (N-vinylPP) formation after administration of 3-[(arylthio)ethyl]sydnone (TTMS) to rats. n-vinylpp cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
3 Cytochrome P-450 (CYP) 3A2 and CYP2C11 are sources of 70 and 30%, respectively, of N-vinylprotoporphyrin IX (N-vinylPP) formation after administration of 3-[(arylthio)ethyl]sydnone (TTMS) to rats. 3-[(arylthio)ethyl]sydnone cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
4 Cytochrome P-450 (CYP) 3A2 and CYP2C11 are sources of 70 and 30%, respectively, of N-vinylprotoporphyrin IX (N-vinylPP) formation after administration of 3-[(arylthio)ethyl]sydnone (TTMS) to rats. 3-(2-(2,4,6-trimethylphenyl)thioethyl)-4-methylsydnone cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
5 Female rats receiving TTMS were pretreated with dexamethasone, which induces CYP3A1 preferentially to CYP3A2. Dexamethasone cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus