Title : Intracellular signaling in rat cultured vascular smooth muscle cells: roles of nuclear factor-kappaB and p38 mitogen-activated protein kinase on tumor necrosis factor-alpha production.

Pub. Date : 1999 Aug

PMID : 10433212






2 Functional Relationships(s)
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1 Different types of NF-kappaB inhibitors, pyrrolidine dithiocarbamate and MG132, which specifically abolished IkappaB degradation and subsequent NF-kappaB activation by LPS, suppressed TNF alpha secretion from VSMC. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor necrosis factor Rattus norvegicus
2 TNF alpha messenger RNA expression induced by LPS was inhibited by pyrrolidine dithiocarbamate, MG132, and SB203580, but not by PD98059. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor necrosis factor Rattus norvegicus