Pub. Date : 1999 Jun 11
PMID : 10386583
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP3A4-transfected microsomes had the most effective potential of nitric oxide formation from isosorbide dinitrate. | Isosorbide Dinitrate | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Anti-CYP3A2 antibody (which cross-reacts with CYP3A4) or ketoconazole (an inhibitor of the CYP3A superfamily) inhibited nitric oxide formation from isosorbide dinitrate in rat heart microsomes. | Isosorbide Dinitrate | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
| 3 | Anti-CYP3A2 antibody (which cross-reacts with CYP3A4) or ketoconazole (an inhibitor of the CYP3A superfamily) inhibited nitric oxide formation from isosorbide dinitrate in rat heart microsomes. | Isosorbide Dinitrate | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | These results suggest that the CYP3A4-NADPH-cytochrome P450 reductase system specifically participates in nitric oxide formation from isosorbide dinitrate. | Isosorbide Dinitrate | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |