Pub. Date : 1999 May
PMID : 10231436
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Free arachidonic acid (AA) activates several protein kinases, and because IL-1 rapidly stimulates phospholipase A2 (PLA2) activity release AA, IL-1-induced activation of JNK1/SAPK may be mediated by AA release. | Arachidonic Acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Pretreatment of MCs with aristolochic acid, a PLA2 inhibitor, concordantly reduced IL-1-regulated [3H]AA release and JNK1/SAPK activity, suggesting that cytosolic AA in part mediates IL-1-induced JNK1/SAPK activation. | aristolochic acid I | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Pretreatment of MCs with aristolochic acid, a PLA2 inhibitor, concordantly reduced IL-1-regulated [3H]AA release and JNK1/SAPK activity, suggesting that cytosolic AA in part mediates IL-1-induced JNK1/SAPK activation. | aristolochic acid I | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | This effect was AA specific, as only AA and its precursor linoleic acid stimulated JNK1/SAPK activity. | Linoleic Acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Furthermore, stimulation of MCs with the exogenous cyclooxygenase-, lipoxygenase-, phosphodiesterase-, and epoxygenase-derived arachidonate metabolites, in contrast to AA itself, did not activate JNK1/SAPK. | Arachidonic Acid | mitogen-activated protein kinase 8 | Homo sapiens |