Title : JNK/SAPK activity contributes to TRAIL-induced apoptosis.

Pub. Date : 1999 Feb

PMID : 10200559






3 Functional Relationships(s)
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1 Death signaling as well as JNK/SAPK activation by TRAIL in these cells is FADD- and caspase-dependent since dominant-negative FADD or the caspase inhibitor zVAD prevented both, apoptosis and JNK/SAPK activity. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone mitogen-activated protein kinase 8 Homo sapiens
2 Death signaling as well as JNK/SAPK activation by TRAIL in these cells is FADD- and caspase-dependent since dominant-negative FADD or the caspase inhibitor zVAD prevented both, apoptosis and JNK/SAPK activity. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone mitogen-activated protein kinase 8 Homo sapiens
3 JNK/SAPK activity in response to triggering of CD95 by an agonistic antibody (alphaAPO-1) was also diminished by dominant-negative FADD or zVAD. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone mitogen-activated protein kinase 8 Homo sapiens