Pub. Date : 1999 Mar
PMID : 10098743
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of JNK and c-Abl signalling by cisplatin and oxaliplatin in mismatch repair-proficient and -deficient cells. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Induction of JNK and c-Abl signalling by cisplatin and oxaliplatin in mismatch repair-proficient and -deficient cells. | Oxaliplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | To identify the signal transduction pathways with which the detector communicates, we investigated the effect of loss of DNA mismatch repair on activation of known damage-responsive pathways, and recently reported that cisplatin differentially activates c-Jun NH2-terminal kinase (JNK) and c-Abl in repair-proficient vs.-deficient cells. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | To identify the signal transduction pathways with which the detector communicates, we investigated the effect of loss of DNA mismatch repair on activation of known damage-responsive pathways, and recently reported that cisplatin differentially activates c-Jun NH2-terminal kinase (JNK) and c-Abl in repair-proficient vs.-deficient cells. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | The results confirm that cisplatin activates JNK kinase 5.7 +/- 1.5 (s.d. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | The DNA mismatch repair system plays an important part in the recognition of cisplatin adducts, and activation of both the JNK and c-Abl kinases in response to cisplatin damage is dependent on the detector function of the DNA mismatch repair proteins. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | The DNA mismatch repair system plays an important part in the recognition of cisplatin adducts, and activation of both the JNK and c-Abl kinases in response to cisplatin damage is dependent on the detector function of the DNA mismatch repair proteins. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |