Pub. Date : 1999 Apr
PMID : 10098509
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We investigated whether and how TSH, which promotes the proliferation and differentiation of thyroid cells, regulates JNK activity in primary cultured human thyroid cells. | Thyrotropin | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | TSH stimulated JNK activity in cytosolic fractions of thyroid cells measured by in vitro kinase assay. | Thyrotropin | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | A low concentration of TSH (10(-11) M) stimulated JNK activity but at a higher dose (10(-8)-10(-7) M), TSH suppressed JNK activity without any change of JNK protein level. | Thyrotropin | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | A low concentration of TSH (10(-11) M) stimulated JNK activity but at a higher dose (10(-8)-10(-7) M), TSH suppressed JNK activity without any change of JNK protein level. | Thyrotropin | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | A low concentration of TSH (10(-11) M) stimulated JNK activity but at a higher dose (10(-8)-10(-7) M), TSH suppressed JNK activity without any change of JNK protein level. | Thyrotropin | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | A low concentration of TSH (10(-11) M) stimulated JNK activity but at a higher dose (10(-8)-10(-7) M), TSH suppressed JNK activity without any change of JNK protein level. | Thyrotropin | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | A low concentration of TSH (10(-11) M) stimulated JNK activity but at a higher dose (10(-8)-10(-7) M), TSH suppressed JNK activity without any change of JNK protein level. | Thyrotropin | mitogen-activated protein kinase 8 | Homo sapiens |
| 8 | We next elucidated the signal transduction pathways in TSH-induced JNK activation by examining the involvement of four distinct intracellular signal molecules; protein kinase C (PKC), cAMP, Ca2+, and PI3-kinase. | Thyrotropin | mitogen-activated protein kinase 8 | Homo sapiens |
| 9 | We next elucidated the signal transduction pathways in TSH-induced JNK activation by examining the involvement of four distinct intracellular signal molecules; protein kinase C (PKC), cAMP, Ca2+, and PI3-kinase. | Cyclic AMP | mitogen-activated protein kinase 8 | Homo sapiens |
| 10 | The stimulation of JNK by TSH was blocked by two PKC inhibitors and suppressed by 8-bromo-cAMP or forskolin. | 8-Bromo Cyclic Adenosine Monophosphate | mitogen-activated protein kinase 8 | Homo sapiens |
| 11 | The stimulation of JNK by TSH was blocked by two PKC inhibitors and suppressed by 8-bromo-cAMP or forskolin. | Colforsin | mitogen-activated protein kinase 8 | Homo sapiens |
| 12 | These findings demonstrate that TSH regulates JNK activity biphasically in human thyroid cells through an interaction between Gi-PKC and cAMP-PKA pathways. | Cyclic AMP | mitogen-activated protein kinase 8 | Homo sapiens |