Pub. Date : 1999 Mar
PMID : 10074490
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have investigated the cellular pathology of the syndrome called thiamine-responsive megaloblastic anemia (TRMA) with diabetes and deafness. | Thiamine | solute carrier family 19 member 2 | Homo sapiens |
| 2 | TRMA fibroblasts were rescued from death with 10-30 nM thiamine (in the range of normal plasma thiamine concentrations). | Thiamine | solute carrier family 19 member 2 | Homo sapiens |
| 3 | TRMA fibroblasts were rescued from death with 10-30 nM thiamine (in the range of normal plasma thiamine concentrations). | Thiamine | solute carrier family 19 member 2 | Homo sapiens |
| 4 | At 30 nM thiamine, the rate of uptake of thiamine by TRMA fibroblasts was 10-fold less than that of wild-type, and cells from obligate heterozygotes had an intermediate phenotype. | Thiamine | solute carrier family 19 member 2 | Homo sapiens |
| 5 | At 30 nM thiamine, the rate of uptake of thiamine by TRMA fibroblasts was 10-fold less than that of wild-type, and cells from obligate heterozygotes had an intermediate phenotype. | Thiamine | solute carrier family 19 member 2 | Homo sapiens |
| 6 | Transfection of TRMA fibroblasts with the yeast thiamine transporter gene THI10 prevented cell death when cells were grown in the absence of supplemental thiamine. | Thiamine | solute carrier family 19 member 2 | Homo sapiens |
| 7 | We therefore propose that the primary abnormality in TRMA is absence of a high-affinity thiamine transporter and that low intracellular thiamine concentrations in the mutant cells cause biochemical abnormalities that lead to apoptotic cell death. | Thiamine | solute carrier family 19 member 2 | Homo sapiens |