Title : Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors.

Pub. Date : 1999 Mar 15

PMID : 10051431






3 Functional Relationships(s)
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1 Activation of JNK in CHO-m3 cells by the agonist methacholine (MCh) was delayed in onset and more sustained relative to that of ERK in either CHO-m2 or CHO-m3 cells. Methacholine Chloride mitogen-activated protein kinase 8 Homo sapiens
2 Activation of JNK in CHO-m3 cells by the agonist methacholine (MCh) was delayed in onset and more sustained relative to that of ERK in either CHO-m2 or CHO-m3 cells. Methacholine Chloride mitogen-activated protein kinase 8 Homo sapiens
3 Agonist-stimulated Ins(1,4,5)P3 accumulation in CHO-m3 cells was insensitive to pertussis toxin (PTX), consistent with a Gq/phosphoinositide-specific phospholipase C-beta mediated pathway, whereas a significant component of ERK and JNK activation in CHO-m3 cells was PTX-sensitive, indicating Gi/o involvement. Inositol 1,4,5-Trisphosphate mitogen-activated protein kinase 8 Homo sapiens