Pub. Date : 1998 Dec 28
PMID : 10022227
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The enterotoxic antimetabolite 5-fluorouracil (5-FU) induced acute p53-dependent apoptosis in the crypts of both small intestine and midcolon. | Fluorouracil | transformation related protein 53, pseudogene | Mus musculus |
| 2 | The enterotoxic antimetabolite 5-fluorouracil (5-FU) induced acute p53-dependent apoptosis in the crypts of both small intestine and midcolon. | Fluorouracil | transformation related protein 53, pseudogene | Mus musculus |
| 3 | In p53 null (-/-) mice significant reductions in 5-FU-induced apoptosis and relief from the inhibition of cell cycle progression permitted retention of crypt integrity after 5-FU. | Fluorouracil | transformation related protein 53, pseudogene | Mus musculus |
| 4 | Importantly, the tissue toxicity of 5-fluorouracil was genetically determined at a locus (p53) separate from that directly associated with toxin action. | Fluorouracil | transformation related protein 53, pseudogene | Mus musculus |