Title : Reduced lecithin:retinol acyl transferase activity in cultured squamous cell carcinoma lines results in increased substrate-driven retinoic acid synthesis.

Pub. Date : 1999 Jan 4

PMID : 9989277






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In parallel with this, unesterified retinol and retinoic acid concentrations in SCC were significantly elevated over those in normal cells. Tretinoin serpin family B member 3 Homo sapiens
2 Challenging cells with increasing medium retinol concentrations resulted in dose-dependent increases in retinol and retinoic acid within SCC. Tretinoin serpin family B member 3 Homo sapiens
3 Consistent with increased substrate-driven retinoic acid synthesis in SCC, the expression of transglutaminase 1 was suppressed to a greater extent in the SCCs than in NHK, when cells were exposed to equivalent medium concentrations of retinol. Tretinoin serpin family B member 3 Homo sapiens